PRECLINICAL PUBLICATION · 2017

The pivotal role of HIF-1alpha in lung inflammatory injury induced by septic mesenteric lymph.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole)

PMID 28478272 ↗2017Reported benefit

The pivotal role of HIF-1alpha in lung inflammatory injury induced by septic mesenteric lymph.

RatOtherSprague-DawleyMaleIntratracheal delivery

Model: Acute lung injury induced by injection of septic mesenteric lymph

Septic lymph raised lung injury scores, myeloperoxidase and HIF-1alpha expression, and intratracheal YC-1 significantly attenuated the lung inflammatory damage.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.