Ellagic acid protects against arsenic trioxide-induced cardiotoxicity in rat.
RatChemical/toxinWistarMalen = 32 rats in four groupsOral30 mg/kgPretreatment 1 hour before each arsenic trioxide injection
Model: Arsenic trioxide-induced cardiotoxicity, arsenic trioxide 5 mg/kg intraperitoneally daily for 10 days
Ellagic acid pretreatment reduced arsenic trioxide-induced changes in glutathione peroxidase and malondialdehyde, shortened QTc prolongation and lowered troponin I and creatine kinase MB, with less cardiac tissue damage.
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