Protective Effects and Mechanisms of Shenhua Tablet on Toll-Like Receptors in Rat Model of Renal Ischemia-Reperfusion Injury.
RatIschaemia-reperfusionRenalWistarMalen = 60 rats in five groups1.5 g/kg/day low dose and 3.0 g/kg/day high doseTreatment for one week before ischaemia-reperfusion surgery
Model: Renal ischaemia-reperfusion injury induced surgically, assessed at 24 and 72 hours
Shenhua Tablet, most markedly at the high dose, reduced renal functional and pathological injury and downregulated toll-like receptor 2 and 4 and myeloid differentiation factor 88 signalling with associated falls in tumour necrosis factor alpha and interleukin-6.
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