The efficacy of human placenta-derived mesenchymal stem cells on radiation enteropathy along with proteomic biomarkers predicting a favorable response.
MouseRadiationC57BL/6JFemalen = 10 mice per group in the first experiment, 8 per group acro…Intravenous via tail vein, 200 microlitres per injectionTherapeutic schedule on days 1, 4 and 7 after irradiation; a further experiment…
Model: Single total body irradiation of 7 Gy using a Gammacell 300 unit for radiation enteropathy; a separate lethality experiment used 10 Gy total body irradiation
Human placenta-derived mesenchymal stem cells given before, after or both before and after irradiation reduced intestinal pathology and inflammation and raised survival after 10 Gy total body irradiation to 100 per cent at 9 days and 70 per cent at 15 days.
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