Inhibition of epidermal growth factor receptor attenuates LPS-induced inflammation and acute lung injury in rats.
RatEndotoxin/LPSSprague-Dawleyn = 48 rats, 8 per group across six groupsIntragastric, oral20 mg/kg body weight in 0.5 per cent carboxymethylcellulose…Pretreatment for 7 consecutive days before intratracheal lipopolysaccharide
Model: Acute lung injury induced by a single intratracheal instillation of lipopolysaccharide 5 mg/kg in 0.9 per cent saline, assessed 24 hours later
Oral pretreatment with either epidermal growth factor receptor inhibitor reduced lung injury score, oedema, inflammatory cell influx, myeloperoxidase and inflammatory gene expression, with compound 451 more potent than AG1478.
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