Efficacy of a combination thromboxane receptor antagonist and lipoxygenase inhibitor in traumatic shock.
RatOtherInbred strain not specified1 mg/kg per h; 20 micrograms/ml in the lung fragment leukot…During traumatic shock
Model: Noble-Collip drum traumatic shock in pentobarbital (35 mg/kg) anaesthetised rats
Vehicle-treated traumatic shock rats survived 82 +/- 12 min with a 20-fold rise in plasma cathepsin D and 6-fold rise in myocardial depressant factor. L-655,240 prolonged survival to 206 +/- 26 min (P less than 0.01) and reduced plasma myocardial depressant factor activity from 74 +/- 3 to 46 +/- 4…
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