Local delivery of chondroitinase ABC with or without stromal cell-derived factor 1alpha promotes functional repair in the injured rat spinal cord.
RatSpinal cord injuryCompressionSprague-DawleyFemaleLocalised intrathecal delivery from crosslinked methylcellulose hydrogel with embedded polymeric nanoparticlesAcute treatment after injury
Model: Impact-compression spinal cord injury
Chondroitinase ABC alone or combined with stromal cell-derived factor 1 alpha produced faster and more sustained behavioural improvement with reduced chondroitin sulphate proteoglycans and wider neural precursor cell distribution, while stromal cell-derived factor 1 alpha alone had no apparent effe…
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