PRECLINICAL PUBLICATION · 2017

Akt1/NFkB signaling pathway activation by a small molecule DMA confers radioprotection to intestinal epithelium in xenograft model.

Mouse / Radiation

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

DMA (5-(4-methylpiperazin-1-yl)-2-[2'-(3,4-dimethoxy-phenyl)-5'-benzimidazolyl]-benzimidazole)

PMID 28435051 ↗2017Reported benefit

Akt1/NFkB signaling pathway activation by a small molecule DMA confers radioprotection to intestinal epithelium in xenograft model.

MouseRadiationBALB/c and nude miceOral and intravenous routes both examined for pharmacokineticsSingle dose given prior to irradiation

Model: Sublethal and supralethal total body irradiation

A single pre-irradiation dose of DMA enhanced survival and reduced haematopoietic and gastrointestinal damage while maintaining endogenous antioxidant status, without protecting tumour tissue.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.