Ameliorative Effects and Possible Molecular Mechanism of Action of Black Ginseng (Panax ginseng) on Acetaminophen-Mediated Liver Injury.
MouseChemical/toxinICRMalen = 8 animals per group across 4 groups, 32 totalOral gavage300 mg/kg and 600 mg/kg body weight per dayPretreatment, for 7 consecutive days before acetaminophen challenge on day 7
Model: Acetaminophen 250 mg/kg given on day 7, producing severe acute liver injury at 24 h
Black ginseng pretreatment significantly reduced serum transaminases and malondialdehyde, raised hepatic glutathione, suppressed apoptotic signalling and limited necrosis and inflammatory infiltration after acetaminophen overdose.
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