Transforming growth factor beta plays an important role in enhancing wound healing by topical application of Povidone-iodine.
RatWoundSprague-DawleyMalen = n = 12 per groupTopical0.5% povidone-iodine applied on gauze dressingFrom day 0, the day of wounding
Model: Four full-thickness excisional dorsal skin wounds made with a 10 mm sterile punch under isoflurane and ketamine anaesthesia
Topical 0.5% povidone-iodine accelerated acute wound healing through increased TGF-beta and alpha smooth muscle actin expression, greater neovascularisation and re-epithelialisation, and this benefit was abolished by TGF-beta inhibition.
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