Significant curative functions of the mesenchymal stem cells on methotrexate-induced kidney and liver injuries in rats.
RatChemical/toxinWistarMalen = 5 groups; group sizes not statedInjection, single administration; specific route not stated2 x 10^6 cells (cell number reported as 2 x 10 cells in the…After methotrexate dosing
Model: Methotrexate 14 mg/kg given orally as a single dose per week for 2 weeks
Both bone marrow-derived and adipose-derived mesenchymal stem cells alleviated methotrexate-induced oxidative stress, biochemical derangement and histological damage in kidney and liver, to a greater extent than dexamethasone.
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