Pentraxin-3 modulates lipopolysaccharide-induced inflammatory response and attenuates liver injury.
MixedEndotoxin/LPSC57BL/6Malen = Mouse group sizes not stated; human cohort 54 patients with…Intraperitoneal5 mg/kg body weight2 hours before intravenous lipopolysaccharide
Model: Chronic liver injury with carbon tetrachloride 0.5 mL/kg intraperitoneally twice weekly for 2 weeks, followed by lipopolysaccharide 2.5 mg/kg intravenously to produce acute-on-chronic injury
Recombinant PTX3 attenuated lipopolysaccharide-induced liver injury, inflammation and cell recruitment, and PTX3 expression was raised in patients with alcoholic hepatitis in proportion to disease severity.
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