Peptide valency plays an important role in the activity of a synthetic fibrin-crosslinking polymer.
RatHaemorrhage/shockUncontrolledSprague-Dawley (Charles River Laboratories)MaleIntravenous via jugular vein catheter15 mg/kg injected over 1.5 minutesImmediately after clamp removal
Model: Femoral artery injury with fluid resuscitation; 3 mm longitudinal incision in the clamped left femoral artery after a controlled catheter bleed to a mean arterial pressure of 40 to 50 mmHg, free bleeding for 15 minutes then saline at 3 mL/min/kg up to 60 mL/kg
PolySTAT with a valency of about 4 increased clot firmness by 57% and reduced clot breakdown by 69% versus phosphate-buffered saline, and valencies of 4 and 8 improved survival to 100% and 80% respectively compared with 20% for albumin control.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.