Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury.
RatSpinal cord injuryHemisection / partialSprague-Dawley (HFK Bioscience)Malen = Four main experimental groups, 7 rats per groupIntravenous10 mg/kg zonisamide, redissolved in normal saline at 1 mg/mL6 hours and 4 days after surgery
Model: Right-sided hemisection of the T10 spinal cord with a sharp blade after removal of the dorsal vertebra, under chloral hydrate anaesthesia
Zonisamide-loaded micelles reduced the atrophied cord area, improved Basso Beattie Bresnahan scores at 4 weeks and increased neuron and axon density relative to free drug, blank micelles and saline.
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