Probucol attenuates hyperoxia-induced lung injury in mice.
MouseOtherC57BL/6Femalen = 40 mice in total, 10 per group across four groups (room air…Intratracheal, delivered by IA-1C MicroSprayer130 micrograms per kg in 50 microlitres, equivalent to 100…Pre-treatment, given one day before the start of hyperoxia exposure
Model: Exposure to 95% oxygen for 72 h in a sealed chamber (hyperoxic lung injury as a model of acute respiratory distress syndrome)
Probucol significantly reduced total cells, macrophages, neutrophils and lymphocytes in bronchoalveolar lavage fluid, lowered IL-6, and improved the histological lung injury grade in hyperoxia-exposed mice. It reduced 8-hydroxy-2-deoxyguanosine staining and TUNEL-positive cell numbers, decreased p4…
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