Rapid tissue regeneration induced by intracellular ATP delivery-A preliminary mechanistic study.
MixedWoundNew Zealand whiten = 27 adult rabbits in total; 9 rabbits (72 wounds) for re-epi…Topical to the wound under TegaDerm dressingATP-vesicles containing 10 mM Mg-ATP, approximately 0.5 ml…Immediately after wounding
Model: Four full-thickness 6 mm punch skin wounds to the depth of the cartilage on the ventral side of each ear, in normal and surgically ischaemic ears
Complete re-epithelialisation took 12.06 plus or minus 1.45 days with ATP-vesicles versus 15.72 plus or minus 1.45 days with Regranex in non-ischaemic ears (n = 18, p = 0.00043), and 16.00 plus or minus 3.39 versus 21.61 plus or minus 4.30 days in ischaemic ears (p = 0.0001). Nearly tenfold more ma…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.