Electrical brain stimulation induces dendritic stripping but improves survival of silent neurons after optic nerve damage.
MixedCrushPeripheral-nerve crushMale hooded rats CrL: LIS (Charles River); B6.Cg-Tg(Thy1-YFP)HJrs/J transgenic miceMale (rats); not stated for micen = Rats: crush plus rtACS n = 11, crush plus sham n = 8, sham/…Transcorneal via gold ring electrode with optical gelRats: biphasic square-wave pulses, 10 ms per phase, 200 mic…First stimulation immediately after optic nerve crush (day 0)
Model: Optic nerve crush. Rats: calibrated self-closing forceps for 30 s at 2 mm behind the eyeball with jaws 0.1 mm apart, bilateral. Mice: self-closing tweezers for 5 s at 1 mm posterior to the eyeball
In rats, retinal ganglion cell survival at day 7 was 18.6 plus or minus 9.5% with sham versus 77 plus or minus 9.4% with rtACS (p = 0.01), but visual evoked potentials were abolished in both lesioned groups with no functional recovery (p = 0.592). In Thy1-YFP mice rtACS did not improve survival (53…
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