Effects of CTGF Blockade on Attenuation and Reversal of Radiation-Induced Pulmonary Fibrosis.
MouseRadiationC57BL/6Femalen = 25 mice per group, with a confirmatory study using 10 mice…Transient antibody administration started at several different times before or…
Model: Single 20 Gy thoracic irradiation causing radiation pneumonitis and pulmonary fibrosis
FG-3019 prevented approximately 50 to 80% or reversed approximately 50% of lung remodelling, improved lung function and general health, and rescued mice from lethal irradiation (p less than 0.01). Treatment begun 16 weeks after irradiation reversed established remodelling and restored lung function…
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