The Protective Effects of Helix B Surface Peptide on Experimental Acute Liver Injury Induced by Carbon Tetrachloride.
MixedChemical/toxinC57BL/6Intraperitoneal8 nmol/kg2 h after carbon tetrachloride administration
Model: Acute liver injury induced by carbon tetrachloride administration; serum and liver sampled 24 h after injury
HBSP significantly reduced serum transaminases, lactate dehydrogenase and hepatic pro-inflammatory cytokines, decreased CD3, CD8 and CD68 positive cell numbers and cleaved caspase-3, and reduced apoptosis in vivo. Survival of mice with acute liver injury was increased, and this benefit was abolishe…
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