DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice.
MouseTBIControlled cortical impactC57BL/6 and alpha-smooth muscle actin-GFP transgenic mice on a C57BL/6 backgroundMalen = n = 12 (injury plus saline) and n = 13 (NBP) for contusion…Intraperitoneal for the acute dose, intranasal for repeated dosing100 mg/kg intraperitoneally acutely and 100 mg/kg/day intra…Single intraperitoneal dose within 5 min after injury
Model: Controlled cortical impact under 1.5% isoflurane; 3.5 mm craniotomy 2.0 mm right of the central suture midway between lambda and bregma; 2.0 mm impact tip at 3.0 m/s, 1.0 mm depth, 150 ms contact time
Contusion volume fell from 7.32 plus or minus 0.57 to 5.83 plus or minus 0.69 (p less than 0.05, n = 12 and 13) with fewer TUNEL-positive cells at 1 and 3 days, suppressed caspase activation and reduced NF-kappaB activation, TNF-alpha and IL-1beta. Chronic intranasal treatment increased neurogenesi…
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