Non-thermal air plasma promotes the healing of acute skin wounds in rats.
RatWoundWistarMalen = 41 rats in total (18 control, 23 plasma treated); day 7 pho…Direct topical plasma jet exposure of the wound1 min exposure (right wound) or 2 min exposure (left wound)…First treatment on the day of wounding
Model: Two full-thickness 8 mm punch biopsy excisional wounds on the upper back midline under 2% isoflurane anaesthesia, with carprofen 4.4 mg/kg subcutaneously after wounding
Both 1 and 2 min treatments significantly improved wound closure on day 7 (p less than 0.001 and p less than 0.005), with a shorter epithelial gap after 1 min and reduced granulation tissue thickness and area (p less than 0.05); no differences remained at day 10 and all wounds were closed by day 14…
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