Mild Acute Intermittent Hypoxia Improves Respiratory Function in Unanesthetized Rats With Midcervical Contusion.
RatSpinal cord injuryContusionSprague-DawleyMaleInhalation10% O2, 4% CO2, balance N24 weeks post-injury
Model: Unilateral C3-C4 spinal cord contusion using MASCIS impactor (drop height 6.25 or 12.5 mm), with laminectomy sham
Cervical contusion reduced breathing capacity and phrenic motoneuron number. Acute hypoxia increased frequency and tidal volume in both sham and contused rats, and tidal volume remained significantly elevated at 15 and 30 minutes after intermittent hypoxia in contused but not sham rats, indicating…
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