Does remifentanil attenuate renal ischemia-reperfusion injury better than dexmedetomidine in rat kidney?
RatIschaemia-reperfusionRenalSprague Dawleyn = 30 rats, five groups of 6Intravenous infusionDexmedetomidine 3 microg/kg bolus over 10 minutes then 3 mi…Started after anaesthesia induction and right nephrectomy, at the start of abdo…
Model: Unilateral renal ischaemia-reperfusion after right nephrectomy: left renal artery and vein occluded 30 minutes, reperfusion 30 minutes
Dexmedetomidine kept plasma NGAL at sham levels throughout and reduced necrotic and apoptotic tubular cells, indicating renoprotection. Remifentanil reduced necrotic cell number and tubular damage relative to untreated groups but showed a significant NGAL rise at 6 hours and was less effective than…
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