Early peritoneal dialysis reduces lung inflammation in mice with ischemic acute kidney injury.
MouseIschaemia-reperfusionRenaln = n = 19 per group for blood urea nitrogen and creatinine aft…intraperitoneal via tunnelled PE50 catheterLow dose: 2 mL peritoneal dialysis fluid exchanged every ho…initiated 1 hour after surgery
Model: Ischaemic acute kidney injury by bilateral renal pedicle clamping for 22 or 25 minutes; bilateral nephrectomy and sham operation also used
High dose peritoneal dialysis lowered blood urea nitrogen (59 +/- 1 to 26 +/- 1 mg/dL, P < 0.0001) and serum IL-6 (723 +/- 103 versus 317 +/- 41 pg/mL, P = 0.0012) and reduced lung neutrophil and interstitial macrophage infiltration at 4 hours, but did not alter kidney injury or pulmonary oedema (w…
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