omega-3 Polyunsaturated fatty acids accelerate airway repair by activating FFA4 in club cells.
MouseChemical/toxinBALB/c and FFA4-knockoutMale7.75 mg/kg
Model: Naphthalene-induced acute airway (club cell) injury, single intraperitoneal injection of 30 mg/kg naphthalene
Naphthalene destroyed bronchiolar epithelial cells within a day, with recovery by 21 days in control mice. Omacor accelerated recovery, with epithelial reappearance between 7 and 14 days. The benefit was absent in FFA4-knockout mice, indicating FFA4-dependent club cell proliferation.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.