IL-1beta-induces NF-kappaB and upregulates microRNA-372 to inhibit spinal cord injury recovery.
RatSpinal cord injuryComplete transectionSprague-Dawleymale
Model: Spinal cord injury in rats; exact contusion or transection procedure not stated in available text
Stable overexpression of a miR-372 inhibitor in human neural stem cells rescued IL-1beta-induced impairment, with significant improvements in tissue water content, myeloperoxidase activity and behavioural scores in spinal cord injured rats.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.