Endoscopic shielding technique with a newly developed hydrogel to prevent thermal injury in two experimental models.
MixedBurnUnspecifiedmale and femalen = 24 rats (8 per arm) and 8 pigs with three ulcer sites eachendoscopic topical application, with submucosal injection in one porcine armapplied at the time of the endoscopic lesion, and by prior submucosal injection…
Model: Endoscopically induced colonic thermal lesions and endoscopic mucosal resection ulcers
In rats the hydrogel improved mucosal healing (70 versus 30.3 per cent for saline and 47.2 per cent for hyaluronic acid, P = 0.003) and eliminated mortality and perforation; in pigs mucosal healing rate was higher with the product (90.2 and 91.3 versus 73.1 per cent, P = 0.002) with a non-significa…
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