Moderate traumatic brain injury increases the vulnerability to neurotoxicity induced by systemic administration of 6-hydroxydopamine in mice.
MouseTBIWeight-drop / impact-accelerationSwissintraperitoneal25 mg/kgacute administration during the 4-week post-injury behavioural testing period
Model: Moderate traumatic brain injury using a free weight-drop device, followed 5 hours later by a single intraperitoneal injection of 6-hydroxydopamine 100 mg/kg
Mice given traumatic brain injury plus 6-hydroxydopamine showed significant motor and neurological impairment that was improved by acute levodopa at 25 mg/kg, alongside reduced rostral striatal tyrosine hydroxylase and increased glial fibrillary acidic protein.
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