Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.
MouseChemical/toxinBALB/cMalen = 4-6 mice per group across four groups; 4 per group for Nrf2…Oral gavage (formononetin dissolved in 0.5% CMC-Na)50 mg/kg and 100 mg/kgPre-treatment, given daily for seven consecutive days before the acetaminophen…
Model: Acetaminophen-induced acute liver injury by a single intraperitoneal dose of 300 mg/kg acetaminophen dissolved in PBS pH 7.4
Formononetin at 100 mg/kg reduced hepatic malondialdehyde from 1.97 plus or minus 0.27 to 0.55 plus or minus 0.14 nmol/mg protein, ALT from 955.80 plus or minus 209.40 to 46.90 plus or minus 20.40 IU/L and AST from 1533.80 plus or minus 244.80 to 56.70 plus or minus 28.80 IU/L (all p < 0.001), rais…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.