UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity.
MouseChemical/toxinFVB/NJ background; UVRAG-deficient mice generated by piggyBac transposition and wild type littermatesn = 3-5 mice per group for histological quantification with abo…DietaryFasting started one day before the first doxorubicin injection; acute endpoints…
Model: Doxorubicin-induced cardiotoxicity; acute model a single intraperitoneal injection of 20 mg/kg doxorubicin in saline, chronic model six intraperitoneal doses of 4 mg/kg at weekly intervals followed by two further weeks before assessment
UVRAG deficiency worsened doxorubicin-induced mortality, cytoplasmic vacuolisation, collagen accumulation, serum lactate dehydrogenase and CK-MB, ROS, apoptosis and cardiac dysfunction, and aggravated the impaired autophagic flux. Intermittent fasting restored autophagic flux and ameliorated the pa…
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