Nanoconjugate-bound adenosine Areceptor antagonist enhances recovery of breathing following acute cervical spinal cord injury.
RatSpinal cord injuryHemisection / partialSprague-DawleyMaleIntradiaphragmatic0.15 microgram/kgGiven at the time of the C2 hemisection on day 0
Model: C2 spinal cord hemisection (cervical hemisection) on day 0
A single intradiaphragmatic administration of nanoconjugate-bound DPCPX facilitated recovery of tidal volume and minute ventilation after cervical spinal cord injury in unanaesthetised rats and attenuated the injury-associated increase in respiratory frequency.
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