Protected graft copolymer-formulated fibroblast growth factors mitigate the lethality of partial body irradiation injury
MouseRadiationC57BL/6J for the irradiation studies; CD1 for the pharmacokinetic studiesmale C57BL/6J for the irradiation studies; female CD1 for the pharmacokinetic studiesn = n = 30 per group across eight groups in the survival study;…Subcutaneous at 10 ml/kg; amifostine intraperitonealPF4 3 mg/kg; PF7 3 mg/kg; PF4/7 combination 1.5 mg/kg each;…First dose 24 h after partial body irradiation; amifostine positive control 30…
Model: Partial body irradiation targeting the gastrointestinal tract, 15.7 Gy (LD50/30) to the lower body with head, forelimbs and thorax shielded, using a 6 MV LINAC photon source at up to 100 cGy/min
PF4 or PF7 given subcutaneously from 24 h after 15.7 Gy partial body irradiation produced 93.3 percent survival versus 60 percent in irradiated controls (p<0.0023). PF4 and PF7 were not significantly different from the amifostine positive control, and PF7 gave the most pronounced mitigation. Unform…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.