The Differential Effect of Apyrase Treatment and hCD39 Overexpression on Chronic Renal Fibrosis After Ischemia-Reperfusion Injury
MouseIschaemia-reperfusionRenalC57BL/6 (from MeSH indexing); human CD39 transgenic line and wild-type littermatesmale (from MeSH indexing)Single dose administered before ischaemia-reperfusion injury
Model: Unilateral renal ischaemia-reperfusion injury
A single dose of soluble apyrase before ischaemia-reperfusion injury reduced acute renal injury at 24 h and renal fibrosis at 4 weeks versus vehicle, and lowered renal ATP, ADP and AMP but not adenosine during ischaemia. In contrast, human CD39 transgenic mice were protected from acute injury at 24…
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