An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury
MouseSpinal cord injuryUnspecifiedC57BL/6 wild-type; SIRT1 knockout generated with the Mx1-Cre/loxP recombination systemfemale (from MeSH indexing)
Model: Spinal cord injury in mice; injury method, level and severity not stated in the available source
SIRT1 expression at the lesion site fell 4 h after spinal cord injury and remained reduced for 3 days. SRT1720 significantly improved functional recovery for up to 28 days and promoted neuronal survival, with reduced proinflammatory cytokines and fewer M1 macrophages, macrophages and microglia and…
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