Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury
MouseChemical/toxinC57BL/6Malen = Partial hepatectomy: 12 mice per cocktail group and 10 in t…IntraperitonealValproic acid 100 mg/kg, lithium carbonate 60 mg/kg, LY2157…6 hours after partial hepatectomy or 6 hours after carbon tetrachloride adminis…
Model: Two acute liver injury models: 2/3 partial hepatectomy, and fulminant hepatic failure induced by intraperitoneal carbon tetrachloride (5% CCl4 in olive oil, 10 ml/kg body weight)
Both cocktails increased hepatocyte proliferation and the liver to body weight ratio after partial hepatectomy, and significantly lowered serum alanine and aspartate transaminase and attenuated hepatocyte ballooning and necrosis after carbon tetrachloride, with elevated pluripotency gene and IL-6 e…
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