The Alternative Receptor for Complement Component 5a, C5aR2, Conveys Neuroprotection in Traumatic Spinal Cord Injury
MouseSpinal cord injuryContusionC57BL/6 wild-type and C5ar2 knockoutFemale (from MeSH indexing)Acute treatment after spinal cord injury; exact start time and duration not sta…
Model: Contusive spinal cord injury in wild-type and C5ar2 knockout mice
Loss of C5aR2 lowered acute intraparenchymal TNF-alpha and IL-6 but worsened outcome, with larger lesion volumes, reduced myelin sparing and poorer functional recovery than wild-type controls, without changes in leukocyte mobilisation or neutrophil recruitment. Acute treatment with the C5aR1 antago…
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