Exosomes Derived from Akt-Modified Human Umbilical Cord Mesenchymal Stem Cells Improve Cardiac Regeneration and Promote Angiogenesis via Activating Platelet-Derived Growth Factor D
RatIschaemia-reperfusionCardiacSprague-Dawleyn = Nine rats per group across five groups (PBS, Exo, GFP-Exo,…Intravenous via the tail vein400 micrograms of exosomal protein per ratImmediately after left anterior descending coronary artery ligation
Model: Acute myocardial infarction created by ligation of the left anterior descending coronary artery with 6-0 suture under anaesthesia and mechanical ventilation
All exosome groups improved cardiac function relative to PBS (P<0.001), and Akt-Exo gave a significantly greater improvement in the 1 to 5 week change in LVEF, LVFS and LVID at end systole than unmodified exosomes (P<0.05). Myocardial apoptosis was reduced by all exosome types with no difference be…
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