Zinc Sulfate and/or Growth Hormone Administration for the Prevention of Radiation-Induced Dermatitis: a Placebo-Controlled Rat Model Study
RatRadiationSprague-DawleyMaleGrowth hormone subcutaneous; zinc oralGrowth hormone 0.01 IU per kg per day; zinc 5 mg per kg per…
Model: Radiation-induced skin injury produced by a single 30 Gy dose of gamma irradiation to the right hind legs
Irradiation produced dermatitis relative to non-irradiated controls (P<0.05). Radiodermatitis severity was significantly lower in the growth hormone, zinc and combined groups than in the irradiation only group (P<0.05), and dermatitis appeared earlier in the irradiation only group (P<0.05). Both ag…
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