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← Studies/PMID 28148233
PRECLINICAL PUBLICATION · 2017

Supplement of levosimendan to epinephrine improves initial resuscitation outcomes from asphyxial cardiac arrest

Rat / Ischaemia-reperfusion

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PMID 28148233 ↗2017Reported benefit

Supplement of levosimendan to epinephrine improves initial resuscitation outcomes from asphyxial cardiac arrest

RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMalen = 10 rats per group in three groups, 30 in total, with a powe…Intravenous, via right femoral vein cannulationLevosimendan bolus 12 micrograms/kg in 1.2 mL followed by i…Given during cardiopulmonary resuscitation, which began 1 min after the onset o…

Model: Asphyxial cardiac arrest induced by stopping mechanical ventilation in urethane-anaesthetised, tracheotomised and instrumented rats, with arrest defined as mean arterial pressure below 10 mmHg after about 3 min, followed by cardiopulmonary resuscitation with chest compressions at about 300 per minute to a depth of 1 cm; associated acute lung injury assessed after resuscitation

Return of spontaneous circulation occurred in 10 of 10 rats given epinephrine plus levosimendan, 8 of 10 given epinephrine alone and 2 of 10 given levosimendan alone (p < 0.001), and survival at 60 min was 10, 4 and 2 rats respectively (p = 0.001). Coronary perfusion pressure and mean arterial pres…

Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.