Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury.
MouseSpinal cord injuryContusionPAR-1 null on a C57BL/6 background, and wild-type C57BL/6Malen = Total n = 100 adult male mice; n = 28 for neutrophil quanti…Intravenous bolus of 0.3 mL followed immediately by a 0.3 mL subcutaneous dose2 mg/kg body weight in saline20 min after injury
Model: Moderate contusive spinal cord injury at mid-thoracic level, laminectomy at T8 with a 3 g weight dropped 5 cm onto the impactor tip
Recombinant activated protein C given 20 min after contusion improved locomotor recovery in wild-type mice from 14 days post-injury but gave no additional benefit in PAR-1 null mice, indicating a PAR-1 dependent effect. PAR-1 null mice showed less neutrophil infiltration, better barrier integrity,…
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