PRECLINICAL PUBLICATION · 2017

Research on the effect and mechanism of the CXCR-4-overexpressing BMSCs combined with SDF-1alpha for the cure of acute SCI in rats.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Bone marrow stem cells transfected to overexpress CXCR-4, combined with stromal cell-derived factor-1 alpha (SDF-1alpha)

PMID 28121340 ↗2017Reported benefit

Research on the effect and mechanism of the CXCR-4-overexpressing BMSCs combined with SDF-1alpha for the cure of acute SCI in rats.

RatSpinal cord injuryUnspecifiedSprague-Dawley

Model: Acute spinal cord injury, model details not stated in the abstract

Rats receiving CXCR-4 overexpressing bone marrow stem cells combined with SDF-1alpha recovered locomotor function in both early and late periods and had lower apoptosis rates, higher Bcl-2 and lower Bax than the other three groups.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.