Pretreatment with nebivolol attenuates level and expression of matrix metalloproteinases in a rat model of renal ischaemia-reperfusion injury.
RatIschaemia-reperfusionRenalWistar albinoMalen = Twenty Wistar albino rats divided into three groupsPretreatment before ischaemia-reperfusion, exact interval not stated in the abs…
Model: Bilateral clamping of the renal arteries for 45 min followed by 24 h of reperfusion
Nebivolol pretreatment significantly reduced the quantity and expression of MMP-2 and MMP-9 during renal ischaemia-reperfusion injury and lowered tubular injury scores compared with untreated injured rats.
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