Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Nude and Sprague-DawleyMaleIntracortical transplantation into stroke-injured cerebral cortex
Model: Stroke-injured cerebral cortex, model details not stated in the abstract
Grafted human induced pluripotent stem cell-derived cortical neurons received direct synaptic inputs from host brain areas in a pattern resembling that of endogenous cortical neurons, and responded to physiological sensory stimulation, showing functional incorporation into injured cortical circuitr…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.