LYRM03, an ubenimex derivative, attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway.
MouseEndotoxin/LPSC57BL/6MaleIntraperitoneal10 mg/kg in vivo; 100 micromol/L in cultured alveolar macro…After intratracheal lipopolysaccharide challenge, exact interval not stated
Model: Acute lung injury induced by intratracheal injection of lipopolysaccharide at 5 mg/kg
LYRM03 at 10 mg/kg intraperitoneally reduced lipopolysaccharide-induced lung oedema, inflammatory cell infiltration, myeloperoxidase activity, pro-inflammatory cytokine production and iNOS and COX-2 expression, attributed to inhibition of Myd88-dependent TLR4 signalling.
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