Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury.
RatSpinal cord injuryContusionSprague DawleyFemalen = 72 rats in total: PcTx1-treated n = 12, saline-treated n =…Intraperitoneal loading dose plus subcutaneous osmotic pump implanted between the shoulder bladesIntraperitoneal loading dose of 12.5 micrograms/kg plus sub…Immediately after the contusion injury
Model: Thoracic spinal contusion at T10 by computer-controlled impactor, 2 mm diameter tip, impact velocity 0.30 m/s, penetration depth 1.44 mm, compression time 0.997 s
PcTx1 treated rats scored significantly higher on the BBB scale at 6 weeks than saline controls and had significantly greater preserved dorsolateral white matter area, which correlated with better function. Horizontal ladder, tapered beam, swim performance and FOX3 neuron counts did not differ sign…
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