Radiomitigation and Tissue Repair Activity of Systemically Administered Therapeutic Peptide TP508 Is Enhanced by PEGylation.
MouseRadiationCD-1MaleSystemic injection
Model: Acute radiation injury with assessment of wound closure, aortic ring angiogenic sprouting and DNA repair
PEG5k-TP508 enhanced wound closure after irradiation and angiogenic sprouting relative to equimolar TP508 without extending circulating half-life, while PEG30k-TP508 extended plasma half-life about 19-fold and also showed enhanced biological activity. Intermediate-sized PEGylated derivatives had lo…
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.