Nerolidol Protects Against LPS-induced Acute Kidney Injury via Inhibiting TLR4/NF-kappaB Signaling.
RatEndotoxin/LPSSprague-DawleyMale
Model: Lipopolysaccharide-induced acute kidney injury in rats, with parallel LPS-treated NRK-52E rat proximal tubular cell experiments
Nerolidol dose-dependently reduced LPS-induced renal histopathological injury and lowered blood urea nitrogen and creatinine, inhibited the rise in TNF-alpha and IL-1beta, and suppressed TLR4 expression along with p65 NF-kappaB phosphorylation and nuclear translocation. Overexpression of TLR4 or p6…
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