Protective Effects of Calpain Inhibition on Neurovascular Unit Injury through Downregulating Nuclear Factor-kappaB-related Inflammation during Traumatic Brain Injury in Mice.
MouseTBIControlled cortical impactBALB/cMalen = 108 mice in total; 6 per group for ultrastructure and histo…Intraperitoneal20 mg/kg, dissolved in 0.9 per cent sodium chlorideFirst dose 5 minutes after controlled cortical impact
Model: Controlled cortical impact over the right parietal cortex (3 mm tip, 2 m/s velocity, 85 ms compression time, 1 mm compression depth), described as moderate injury
MDL28170 reduced contusion volume (9.30 plus or minus 1.05 and 9.90 plus or minus 1.17 cubic mm versus 16.90 plus or minus 1.01 and 17.20 plus or minus 1.17 cubic mm), lowered brain water content and Evans blue leakage, improved neurological severity scores (7.50 plus or minus 0.45 and 6.33 plus or…
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