Factors enhancing the migration and the homing of mesenchymal stem cells in experimentally induced cardiotoxicity in rats.
RatChemical/toxinAlbinoFemalen = 50 female rats in total: 10 healthy controls and 40 given d…Intravenous (mesenchymal stem cells)After induction and histopathological confirmation of doxorubicin cardiotoxicity
Model: Doxorubicin-induced acute cardiotoxicity
The greatest biochemical and histopathological improvement was seen in the group receiving mesenchymal stem cells together with sodium valproate and electrical stimulation, indicating that electric fields and valproate enhance homing of the cells to doxorubicin-damaged myocardium.
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