Neuroprotective effect of picroside II in brain injury in mice.
MouseTBIUnspecified20 mg/kg
Model: Four murine brain injury models: traumatic, ischaemic and infectious brain injury
Picroside II at 20 mg/kg improved survival and reduced apoptosis-related proteins, Caspase-3 and acute inflammatory cytokines across traumatic, ischaemic and infectious brain injury models, with downregulation of TLR4 and NF-kappaB. Picroside II alone had no effect.
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